Sant Antoni and Poble Sec are a must if you're a foodie. The two neighbourhoods are next to each other, divided by the Paral·lel, but they are very different from each other.
Restaurants and bars in Poble Sec
Poble Sec has that blue-collar neighborhood feeling to it, with many inexpensive tapas bars and places to go for a cheap beer. It's great for barhopping and it has a very relaxed feeling to it.
Restaurants and bars in Sant Antoni
Sant Antoni is the hip, up-and-coming area. Walk along the Carrer Parlament and you'll find a lot of very interesting bars and restaurants. Healthy food, amazing donuts, cute cafés, adorable bakeries... I'm sure you can spend a whole day here, just eating and drinking!
Here are a few of my favorites: